Indicators on phenobarbital sodium obat apa You Should Know
Indicators on phenobarbital sodium obat apa You Should Know
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Contraindicated (one)pentobarbital will lessen the extent or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with strong CYP3A4 inducers may result in reduced serum concentrations and loss of antimalarial efficacy
pentobarbital will decrease the extent or effect of quinine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.
pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with powerful CYP3A4 inducers; these drugs reduce exposure to vandetanib by as much as 40%.
pentobarbital will minimize the level or effect of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
The speed of IV injection mustn't exceed 50 mg/min for pentobarbital sodium. There isn't any common intravenous dose of NEMBUTAL Sodium Solution (pentobarbital sodium injection) that is often relied on to supply very similar effects in numerous patients. The opportunity of overdose and respiratory melancholy is distant when the drug is injected slowly in fractional doses. A usually used Preliminary dose for the 70 kg adult is a hundred mg. Proportional reduction in dosage needs to be made for pediatric or debilitated individuals. A minimum of a person minute is critical to ascertain the full effect of intravenous pentobarbital. If required, more tiny increments from the drug may be supplied up to a total of from 200 to 500 mg for standard Grownups.
pentobarbital will lower the level or effect of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. The efficacy of hormonal contraceptives could possibly be decreased. Usage of a nonhormonal contraceptive is suggested.
pentobarbital raises toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. CYP3A4 inducers may perhaps increase the metabolism of ifosfamide to its Energetic alkylating metabolites.
pentobarbital will lessen the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
pentobarbital will lessen the extent or effect of netupitant/palonosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Netupitant is mainly metabolized by CYP3A4; steer clear of use in individuals who are chronically utilizing a powerful CYP3A4 inducer
Estradiol, estrone, progesterone more info and other steroidal hormones: Pretreatment with or concurrent administration of phenobarbital may perhaps decrease the effect of estradiol by rising its metabolism.
pentobarbital will reduce the level or effect of eltrombopag by impacting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Monitor.
pentobarbital will lessen the level or effect of zonisamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
pentobarbital will lessen the level or effect of pazopanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
fentanyl transdermal and pentobarbital each increase sedation. Prevent or Use Alternate Drug. Limit use to individuals for whom alternative treatment method selections are insufficient